If you like to work with grid frameworks you’ve probably already looked at 960.gs and Blueprint packages.  If you prefer to work with HTML 5 and are looking for something responsive and modern, take a look at Twitter’s Bootstrap framework.  It has quite a bit going for it like:

  • Styles and Attributes are fully customizable
  • HTML 5 based
  • uses LESS CSS with all attributes set as variables
  • Responsive Design Supported
  • 12 Column by default (adjustable)
  • All elements (including forms) are selected and styled
  • jQuery integrated with easily accessible plug-ins available
  • Webapp that supports adding/removing code to customize and reduce framework size

It’s modern, lightweight and worth a look if you have a project with more functional requirements than budget.