If you like to work with grid frameworks you’ve probably already looked at 960.gs and Blueprint packages. If you prefer to work with HTML 5 and are looking for something responsive and modern, take a look at Twitter’s Bootstrap framework. It has quite a bit going for it like:
- Styles and Attributes are fully customizable
- HTML 5 based
- uses LESS CSS with all attributes set as variables
- Responsive Design Supported
- 12 Column by default (adjustable)
- All elements (including forms) are selected and styled
- jQuery integrated with easily accessible plug-ins available
- Webapp that supports adding/removing code to customize and reduce framework size
It’s modern, lightweight and worth a look if you have a project with more functional requirements than budget.